L-Arginine – A Potential Amino Acid Used Against Erectile Dysfunction

Erectile dysfunction is a widespread disease affecting millions of men worldwide. It is defined as the inability to maintain an erection sufficient for adequate sexual activity. Many etiological factors can lead to this condition, including stress, anxiety, cardiovascular disorders, diabetes, obesity, hypertension, tobacco. All of these causes may restrict the blood flow to veins and arteries. 


Depending on the cause and severity of erectile dysfunction, there are various treatment options:

1. Oral medications:

These are considered the successful erectile dysfunction treatment for any man. They include:

sildenafil, tadalafil, avanafil. All these medications enhance the effects of nitric oxide that results in relaxing muscles in the penis. This increases blood flow and allows a person to get an erection in response to sexual stimulation. Other medications for erectile dysfunction include: 

Alprostadil self-injection, testosterone replacement is a treatment option in case if testosterone levels are low.

1. Penis pumps, penile implants

2. Exercises:

Specific exercises help in improving erectile dysfunction. These exercises include:

  • Aerobic exercises: 
  • Kegels or pelvic floor exercises
  • Pilates exercises

These exercises help to increase the strength of pelvic floor muscles and increase blood flow.

1. L- Arginine therapy:

L- Arginine is a naturally occurring amino acid produced in the human body. It is also found in red meat, fish, poultry, and other protein-rich foods. Its significant benefits include reduced blood pressure and relief from angina. L-Arginine for erections has shown some positive results as well:

  • How does it help in treating erectile dysfunction?

L-Arginine plays an essential role in producing Nitric oxide by the action of nitric synthase enzymes. The production of NO dilates the arteries and veins of the penis, increasing the erections.

  • How effective is L-Arginine?

Most men well tolerate it, but it does not help restore healthy erectile function in most cases. However, L-Arginine, if combined with other supplements, may give a better result. These include:

2. L-Arginine and yohimbine hydrochloride: 

This improved treatment for erectile dysfunction and showed some promising results, but this is only for mild to moderate disease.

3. L-Arginine and pycnogenol:

It helped many men achieve normal erections. It doesn’t have side effects too 

  • Common side effects of L-Arginine

L-Arginine is usually safe, but it can have some side effects. These include:

Nausea, diarrhea, abdominal pain, gout, allergic response, worsening of asthma symptoms, heart attack, etc.

L-Arginine can cross-react with certain medications, including the likes of:

Nitroglycerin, erectile dysfunction medications, anticoagulants and antiplatelet, diabetic drugs, nitrates, diuretics, and isoproterenol.

Bottom Line:

L-Arginine plays can help improve erectile dysfunction; it synthesizes Nitric Oxide that is a vital molecule for vasodilation. Nitric Oxide allows more blood to enter the penis resulting in more robust and firmer erections. Much research has been carried out using L-Arginine to treat erectile dysfunction, and it has shown some positive results. For better results, L-Arginine must be used in combination with certain supplements like pycnogenol and yohimbine. L-Arginine and pycnogenol have helped many men aged between 25 to 45 with erectile dysfunction achieve expected results. L-Arginine has some side effects, and it also cross-reacts with some medications, so the dose and combination therapy must be carefully discussed with a doctor.

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